Department of Biochemistry, Cell Biology and Genetics
First Semester 2018-2019
Course Name: Introduction and Metabolic Biochemistry
Course Num.: 7104210
Instructor:Dr.Suleiman Alkhalil
Credit Hours: 3 THeory / 1 Lab
Perquisites:
Organic Chemistry for Health Sciences (7004002)
Course Description:
This course explores the roles of essential biological molecules focusing on protein chemistry, while covering lipids and carbohydrates. It provides a systematic and methodical application of general and organic chemistry principles. Students examine the structure of proteins, their function, their binding to other molecules and the methodologies for the purification and characterization of proteins. Enzymes and their kinetics and mechanisms are covered in detail. Metabolic pathways are examined from thermodynamic and regulatory perspectives. This course provides the linkage between the inanimate world of chemistry and the living world of biology.
Intended Learning Outcomes ( ILOs):
Upon completion of this course the learner will be expected to:
a. Knowledge and Understanding:
Identify different types of amino acids and their buffer properties.
Clarify the metabolic and regulatory pathways of carbohydrates, lipids, proteins and nucleic acids.
State how amino acids are polymerizing into various versatile types of proteins with their genetic and metabolic relevance.
Describe the structure of heme and proteins of the extra-cellular matrix.
Recognize the nature, mechanism of action and types of enzymes.
Illustrate the classification and physiological significance of different types of carbohydrate
List the biochemical properties and physiologic significance of different types of lipid.
b. Intellectual Skills:
Correlate between clinical features and metabolic disorders.
Identify appropriate methods for metabolic disorders.
Evaluate blood gases, buffers and pH
Analyze the clinical significance of determination of plasma glucose, total proteins, enzymes etc..
Discuss the etiology of metabolic disturbance in a given case study report.
Differentiate between different techniques of biochemistry and their applications.
Criticize research papers in biochemistry
c. Professional and Practical Skills (dry experiments):
Solve results of protein electrophoresis.
Employ increased plasma enzymes level in the diagnosis of some disorders
Use the physical and chemical properties of carbohydrates in determining their functions and locations
Apply chemical tests to study the properties of lipids and fatty acid
Evaluate the physical and chemical properties of amino acids and proteins and estimation of total plasma proteins
Measure the concentration of unknown solutions
Argue tests important for determination of hemoglobin in a blood sample.
d. General and transferable Skills:
Establish life-long self-learning required for continuous professional development.
Use the sources of biomedical information and communication technology to remain current with advances in knowledge and practice.
Retrieve, manage, and manipulate information by all means, including electronic means.
Present information clearly in written, electronic and oral forms.
Establish effective interpersonal relationship to Communicate ideas and arguments.
Work effectively as a member or a leader of an interdisciplinary team.
Textbook:
Ferrier, Denise R. (2017): Lippincott's Illustrated Reviews: Biochemistry; 7th Edition, Lippincott Williams & Wilkins.