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    An-Najah  National University

    Biology and Biotechnology Department
    Cell Biology 10201321
     
    Instructor: Dr Salwa Khalaf
    Credit: lecture 3 hrs.
    Text Book: Becker’s World of the Cell 8th edition (2016). Hardin, Bertoni, and Kleinsmith.
    ______________________________________________________________
    Course Description:
    This course is concerned primarily with eukaryotic cells. Lectures are devoted to structural details and the molecular functions of the different parts of the cell. Lectures will introduce topics such as endocytosis, intramembrane transport, protein targeting, organelle biosynthesis, protein sorting, exocytosis, cell shape, motility, and cell-to-cell interaction. Also, lectures will deal with signal transduction processes, cell cycle, mitosis, cancer, and cellular functions that are required for cell growth and programmed cell death. By its completion, students should have a comprehensive understanding of the architecture and function of living cells.
     
    Course Objectives.
    ♦ Become familiar with the various sub-cellular structures and organelles inside eukaryotic cells
    ♦ Understand how proteins and lipids are synthesized, transported and degraded
    ♦ Learn about vesicular trafficking, endocytosis, and exocytosis
    ♦ Gain an introduction to cellular signal transduction mechanisms (also known as cell signalling)
    ♦ Become familiar with the molecular structure and behaviours of the cytoskeleton
    ♦ Understand the basic events of the cell cycle and the importance of programmed cell death (apoptosis)
    ILOs for the course:
    At the end of this course, the student should be able to
    • Describe the chemical components and processes of cells.
    • Describe the storage of genetic information within cells and how this information is passed on to the next generation.
    • Discuss membrane structure and transport across cell membranes.
    • Discuss the different macromolecule structures and functions.
    • Describe the significant processes involved in the transfer and storage of energy in a cell.
    • Describe the significant processes that occur in cell communication and intracellular transport
    • Describe the life cycle of cells and how these cycles are regulated.
    • Describe the mechanisms involved in gene expression.
    • Discuss the different possible causes of cancer, cellular changes at the molecular level, and the different methods used and proposed for cancer therapy.
    References:
    1. Becker’s World of the Cell 8th edition (2012). Hardin, Bertoni, and Kleinsmith
    2. The World of the Cell, 7th ed (2009), by Becker, Kleinsmith, Harden, and Bertoni
    3. Becker, Kleinsmith, and Hardin, 2006. The World of the Cell, 6th ed. Pearson Benjamin Cummings.
    4. Becker, Kleinsmith, and Hardin, 2004. The World of the Cell, 5th ed. Pearson Benjamin Cummings.
    5. Gerald Karp, 2008. Cell and Molecular Biology; concepts and experiments, 5th ed. John Wiley and sons.
    6. Alberts et al, 2004. Essential Cell Biology, 2nd ed. Garland Science.
    7.  Pollard, T.D. and Earnshaw, W.C. 2002.Cell Biology, 1st ed. Elsevier Science (USA).
    8. Lodish, H. et al. 2002. Molecular Cell Biology, 4th ed. New York: Freeman and Company.
    9. Cooper, G. M., 2000.    The Cell: A molecular approach. 2nd ed. Washington, D. C. ASM press.
    Assessment and Evaluation
    Midterm Exam         30%
    Assignments and Quizzes' 20%
    Final Exam         50%
    ---------------------------
    Total of 100%
     

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    • Announcements

      الطلبة الأعزّاء

      الموضوع: الغياب عن الامتحانات او المحاضرات لأعذار طبيّة

      كل عام وأنتم وشعبنا الفلسطيني، وعالمنا العربي والإسلامي بألف خير، ونرجو لكم السلامة من كلّ شر، والمواظبة على الدّراسة، وتسليم الواجبات، وأداء الامتحانات في مواعيدها، ونحن نقدّر أنّ الظّروف أحياناً قد تؤخّر بعضكم عن ذلك. لكن لا بدّ من نظامٍ واضحٍ يكون مرجعيتنا لضبط الأمور، على وجهٍ منطقيٍّ وسليم.

      وعليه فإنّ التغيّب عن المحاضرة، أو أداء الامتحانات لا يحتسب ضمن الغيابات بعذر، إذا لم يتم احضار سبب مُقنع لمدرّس المساق، ومن بين ذلك العذر الطبّي، ولا يؤخذ به إلا إذا التزم الطالب بما يأتي:

      1. أن يحضر  إلى عيادة الجامعة شخصياً في الفترة الزمنية القانونية، وهي من (1-3) أيام من تاريخ عودته إلى الجامعة، مصطحباً معه التقرير الطبّي حول حالته التي استدعت الغياب.
      2. أن يكون التقرير معتمداً بتوقيع وختم الطبيب المعالج أو المستشفى أو المؤسسة الصادر عنها.
      3. الطالب الذي يمرض خلال الدوام عليه مراجعة عيادة الجامعة، ولن تُقبل التّقارير خلال هذه الفترة من مراكز طبيّة خارجيّة .
      4. على الطلبة الذين يسكنون في مدينة نابلس الالتزام بمراجعة عيادات الجامعة عند المرض في فترة الامتحانات. وعدم التّوجّه إلى عيادات أخرى لأخذ تقارير طبيّة منها.
      5. إرفاق نتائج التحاليل وصور الأشعة وغيرها التي تثبت التشخيص؛ حتّى يتم اعتماد التّقرير.
      6. إذا استدعى الأمر دخول المشفى (لا قدّر الله)، على الطالب إبلاغ رئاسة القسم، والعيادة الجامعيّة.
      7. التقارير الطبية الخاصة بالأسنان معتمدة في حالة وجود قلع جراحي أو غرز طبيّة.
      8. عند الإصابة بالأمراض النفسيّة، أو العصبية، أو أمراض القلب، أو آلام العمود الفقري أو غير ذلك من الحالات التي تحتاج إجازة طويلة فيجب أن تُقدّم تقاريرها حال ظهور المرض مباشرة، ودون تأخير، وبتاريخ واضح يُحدّد الإجازة المرضية بدايةً ونهايةً، ما لم تحدث مضاعفات.
      9. من حق طبيب الجامعة اعتماد التقرير الطبي، أو رفضه، أو  إنقاص  مدة الإجازة المرضية؛ بحسب ما يراه مناسباً وفق طبيعة الحالة.
      10.  يتحمّل الطالب المسؤوليّة القانونيّة إذا ثبت عدم صحّة التّقرير الطبّي.

      مع تمنياتنا لكم بالصحة والسلامة



    • Presentation Evaluation Criteria

      Cell Biology

      2025

       

      Category

      Scoring Criteria

      Total Points

      Score

      Organization

      Information is presented in a logical sequence.

      The presentation appropriately cites references.

      •  

      1

       

      Visual Aids

      Clear and not overcrowded slides

      1

       

       

      The contribution of colours is to understanding, not distracting.


       

       

      Font ( size, style).

      1

       

       

      Figures and images convey results effectively.

      1

       

      Content

      The introduction is attention-getting and lays out the problem nicely.

      •  

      1

       

       

      The presentation contains accurate information.

      1

       

       


       

      There is an obvious conclusion summarizing the presentation.

      1

       

      Presentation

      The speaker maintains good eye contact and is appropriately animated (body language and gestures).

      1

       

       


       

       

      Good language skills and pronunciation are used.

      1

       

       


       

       

      The length of the presentation is within the assigned time limits.

      1

       

      Score

       

      10

       


    • Dear Students

      Please note the following is related to the research project.

      1. You have to record your talk while opening the camera.

      2. Every member of each group should introduce him/herself before the talk.

      3. The duration of the talk is between 10-12 min only.

      4. The last slide of the PowerPoint presentation should include all your references.

      5. You should refer to your references in your slides( CITATION).

      6. Look at the criteria for the presentation evaluation before you record.

      7. The Zoom link and the ppt presentation file should be sent to the assignment section in Moodle.

      8. The Zoom recording link should be written in the last PowerPoint slide.

      Good Luck



    • url icon
      URL
      CELL BIOLOGY BOOK URL
    • zoom icon
      Zoom meeting
      Zoom cell biology 10201321 lectures Zoom meeting
    • url icon
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      9/12/2024 URL
    • url icon
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      8/12/2024 URL
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      2/12/2024 URL
    • url icon
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      1/12/2024 URL
    • url icon
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      25/11/2024 URL
    • url icon
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      24/11/2024 URL
    • resource icon
      File
      Project Groups and Topics File

      Dear students

      Attached is the file for the groups and the project titles assigned to them.

      Please start your preparation and reading related to your topic as soon as possible. 

      You have to read three articles related to the topic.

      Reference citation is very important.

      All the references will be checked online.

      All the articles should be taken from Google Scholar and PupMed sites for published scientific papers.

      The last date for your project's delivery is on the 10th of May 2025.  Nothing will be accepted beyond that date.


      Good Luck



    • Dear Students 

      PLEASE NOTE

      The midterm exam will be on the 23rd of April 2025 at 12:00    

      Room: 141050

      Good Luck


    • Dear Students

      Please note that the maximum number of PowerPoint presentation file slides should not exceed 25 slides, nor should it be less than 20.


    • resource icon
      File
      An Example for the Project PPt File

  • Topic 2

    Membranes: Their Structure, Function, and Chemistry.

    • Introduction:
      To introduce the students to the basic structural components of membranes and their functions.
       
      Objectives:
      1. To know the basic structure of membranes and their components.
      2. To understand how cellular membranes function.
      3. To know the methods used to study cell membranes.
       
      Plan:
      Study the presentations and the recorded lectures listed below.
    • resource icon
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      LECTURE 1 File
    • glossary icon
      Glossary
      Membrane Structure and Function Glossary

      Give one term related to the membranes, their structure and function.

    • url icon
      URL
      13/2/2024 URL
    • url icon
      URL
      14/2/2024 URL

  • Topic 3

    Transport Across Membranes: Overcoming the Permeability Barrier.

    • Introduction:
      Give an idea about the different methods used to transport molecules and ions into and outside the cell. 

       

      Objectives:
      To give the students the information necessary to understand the different methods used by the cell to transport different types of molecules.

       

      Plan:
      1. Study the powerpoint presentation.
      2. Watch the youtube animation.
      3. At the end of the study, the student has to answer the provided homework question.
    • resource icon
      File
      Lecture 3 2021 File
    • glossary icon
      Glossary
      Transport Across Membranes Glossary

    • Porin Structure 15/2/2023


    • Aquaporin Structure  15/2/2023


    • url icon
      URL
      18/2/2024 URL
    • url icon
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      19/2/2024 URL

  • Topic 5

    The Endomembrane System and Peroxisomes.

  • Topic 7

    Signal Transduction Mechanisms: Messengers and Receptors.

    • Introduction:
      To introduce the students to other types of messengers and chemicals produced in the body besides those found in nerve cells.
       
      Objectives:
      1. To study other means of intercellular cellular communication.
      2. To study different types of chemical messengers that are different from the neurotransmitters.
      3. To study other type of receptors found inside or outside the target cells.
       
      Plan:
      The student is advised to study all the presentations and notes from the book first, then answer the proposed homework if there was any.
    • 4.This video describes how signal amplification occurs by hormones and other chemical messengers in the body.
    • 5.Tyrosine Kinase Receptor: Ras Pathway in the following video

    • page icon
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      Tyrosine Kinase Receptor Page
    • resource icon
      File
      Signal Transduction: receptors and messengers File
    • url icon
      URL
      4/3/2024 URL
    • url icon
      URL
      5/3/2024 URL
    • url icon
      URL
      6/3/2024 URL

  • Topic 8

    Beyond the Cell: Cell Adhesion, Cell Junctions and Extracellular Structures.


  • Topic 9

    The Structural Basis of Cellular Information: DNA, Chromosomes and Nucleus.


    • Introduction:
      This chapter gives information about the nature of DNA molecules and how they instruct all the processes that take place in cells. It also shows how information carried by DNA flows both between generations of cells and within each individual cell.
       
      Objectives:
      1. To know the basic structure of DNA molecules.
      2. To understand the organization of DNA in Genomes.
      3. To know how DNA is packaged within the nucleus.
      4. To know the different structural constituents of the nucleus and to know how proteins and nucleic acids are transported between the cytosol and the nucleus.
       
      Plan:
      The student is supposed to study all the presentations as well as the note from the text.
    • 1.DNA and the nucleus

    • 3.DNA sequencing 2

    • 4.DNA packaging
    •  
      5.Transport across nuclear membrane
    • resource icon
      File
      The Structural Bases of cellular Information 2022 File
    • resource icon
      File
      The structural basis of cellular information File
    • glossary icon
      Glossary
      DNA and the Nucleus Glossary
    • url icon
      URL
      28/2/2024 URL
    • url icon
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      3/3/2024 URL

  • Topic 10

    The Cell Cycle: DNA Replication and Mitosis.

    • Introduction:
      This chapter gives an idea about the different events that are associated with the cell cycle focusing on the replication of DNA and the stages of mitotic process.
       
      Objectives:
      1. To know the stages involved in DNA replication in both prokaryotes and eukaryotes.
      2. To know all the enzymes involved in this process.
      3. To know the difference between prokaryotic and eukaryotic DNA replications.
      4.To know the steps involved in the repair of damaged DNA.
      5. To study the regulation of the cell cycle.
      6. To study the changes that characterize the apoptosis process.
       
      Plan:
      Study all the topics from the textbook then study all the presentations provided.
    • 1.Cell cycle 1

    • 4.What is DNA repair and how is it happen
    • page icon
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      Dna repair Page

    •  

      5.Apoptosis 1
    • resource icon
      File
      chapter 19 the cell cycle File
    • resource icon
      File
      Cell Cycle 2022 File
    • glossary icon
      Glossary
      The Cell Cycle Glossary
    • url icon
      URL
      10/3/2024 URL
    • url icon
      URL
      11/3/2024 URL
    • url icon
      URL
      12/3/2024 URL

  • Topic 11

    Cancer Cells.

    • Introduction:
      The chapter deals with cancer disease which is the second leading cause of death after cardiovascular disease. This disease arises from abnormalities in cell function.
      Gene mutations, and changes in gene expression play a central role in this.
         
      Objectives:
      1. To study how the genetic changes contribute to the aberrant properties of cancer cells.
      2. To study the different types of changes that take place in the genes.
      3. To study the causes of these changes.
      5. To study the different types of therapies used for cancer treatment.
       
      Plan:
      The student is supposed to study the notes from the textbook as well as the presentations provided.
    • 1.cell cycle and cancer

    • 2.cancer growth

    • 3.metastasis

    • glossary icon
      Glossary
      Cancer Glossary
    • url icon
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      13/3/2024 URL
    • url icon
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      17/3/2024 URL
    • url icon
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      18/3/2024 URL
    • url icon
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      19/3/2024 URL
    • url icon
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      20/3/2024 URL
    • resource icon
      File
      Cancer cells File

  • Topic 12

    Cytoskeletal Elements

    Introduction: 

    This chapter is concerned with the interior structure of eukaryotic cells. It gives an idea about the cytoskeleton which is a complex network of interconnected filaments and tubules that extend through the cytosol. The cytoskeleton plays important roles in cell division, cell movement, movement of membrane-bounded organelles within the cytosol and other functions.

    This system is involved in the modulation of events and it is altered by other events.

    Objectives:

    1. To introduce the students to the structural elements of the cytoskeletal system.

    2. To know the structural bases for each component.

    3. To know the function involved by each component.

    Plan:

    After studying the major topic related to this chapter from the textbook, the student can review them by looking at the following presentations.

  • Topic 13

    Quizzes and Assignments Evaluation





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